CD11b antibody (Integrin alpha M) (AA 50-100)

Details for Product anti-ITGAM Antibody No. ABIN730918, Supplier: Log in to see
Antigen
  • CD11b/CD18
  • CR3
  • CR3A
  • Cd11b
  • F730045J24Rik
  • Ly-40
  • MAC1
  • Mac-1
  • Mac-1a
  • CD11B
  • MAC-1
  • MAC1A
  • MO1A
  • SLEB6
  • C3bi
  • integrin subunit alpha M
  • integrin alpha M
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • integrin alpha-M
  • ITGAM
  • Itgam
  • LOC100351865
Alternatives
anti-Human CD11b antibody for Immunoprecipitation
Epitope
AA 50-100
39
19
17
15
14
14
9
8
8
8
7
6
5
5
5
5
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
754
501
174
105
37
33
32
25
14
13
10
10
9
8
6
5
4
4
2
2
Host
Rabbit
537
413
160
17
4
2
Clonality
Polyclonal
Conjugate
This CD11b antibody is un-conjugated
146
125
97
62
19
17
16
16
14
14
14
13
12
11
9
9
9
8
8
7
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4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
926
272
223
200
169
166
91
91
90
62
26
21
13
12
9
8
5
5
4
3
3
2
1
1
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human CD11b
Isotype IgG
Specificity The immunogen of this product has partial sequence similarity to CD11d and may cross react.
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others CD11b products on genomics-online (e.g. as negative or positive controls)
Alternative Name CD11b/c (ITGAM Antibody Abstract)
Background

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Subcellular location: Extracellular

Synonyms: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, ITGAM, Integrin alpha-X, ITGAX, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11c

Gene ID 3684
UniProt P11215
Pathways Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
Application Notes WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Integrin alpha M (ITGAM) (AA 50-100) antibody (ABIN730918) Formalin-fixed and paraffin embedded mouse brain tissue labeled with Anti-CD11b/Integ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Integrin alpha M (ITGAM) (AA 50-100) antibody (ABIN730918) Formalin-fixed and paraffin embedded mouse brain tissue labeled with Anti-CD11b/Integ...
Flow Cytometry (FACS) image for anti-Integrin alpha M (ITGAM) (AA 50-100) antibody (ABIN730918) Human U937 cells probed with CD11b/c Polyclonal Antibody, Unconjugated ) (0.2ug) for...
Western Blotting (WB) image for anti-Integrin alpha M (ITGAM) (AA 50-100) antibody (ABIN730918) This image was kindly submitted by Kandy Velazquez from USC School of Medicine. Mouse...
Product cited in: Yamaguchi, Sato, Kato-Itoh, Goto, Hara, Sanbo, Mizuno, Kobayashi, Yanagida, Umino, Ota, Hamanaka, Masaki, Rashid, Hirabayashi, Nakauchi: "Interspecies organogenesis generates autologous functional islets." in: Nature, Vol. 542, Issue 7640, pp. 191-196, 2017 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Mouse (Murine)). Further details: Sample: pancreas

Velázquez, Enos, McClellan, Cranford, Chatzistamou, Singh, Nagarkatti, Nagarkatti, Fan, Murphy: "MicroRNA-155 deletion promotes tumorigenesis in the azoxymethane-dextran sulfate sodium model of colon cancer." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 310, Issue 6, pp. G347-58, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: colon

Kobayashi, Tanizaki, Kimura, Ishida, Nosaka, Toujima, Kuninaka, Minami, Ino, Kondo: "AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian cancer." in: European journal of pharmacology, Vol. 766, pp. 63-75, 2015 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Mouse (Murine)).

Zhang, Hu, Liu, Ye, Gui, Zhou, Qi, He, Wang, Wang: "CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment." in: Scientific reports, Vol. 5, pp. 15948, 2015 (PubMed). Method employed by authors: Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (Sample species: Mouse (Murine)). Further details: Sample: intestines

Liu, Xie, Ma, Zhang, Liang, Shi, Yu, Feng, Zhang, Wu: "Gr-1+CD11b+ cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation." in: Scientific reports, Vol. 4, pp. 4833, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Mouse (Murine)).

Yu, Yang, Wang, Chen, Lu, Luo, Wang: "Ethanol supports macrophage recruitment and reinforces invasion and migration of lewis lung carcinoma." in: Alcoholism, clinical and experimental research, Vol. 38, Issue 10, pp. 2597-606, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Mouse (Murine)).

Long, Qiu, Wang, Yang, Jia, Xin, Wang, Han, Fei, Liu: "Genetically engineered bone marrow mesenchymal stem cells improve functional outcome in a rat model of epilepsy." in: Brain research, Vol. 1532, pp. 1-13, 2013 (PubMed). (Sample species: Rat (Rattus)).

Long, Qiu, Liu, Fei, Feng, Wang, Zhong, Yi, Liu, Zhang, Han: "Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells." in: Neuroscience, Vol. 212, pp. 214-24, 2012 (PubMed).

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