SLC8A1 antibody (AA 801-900)

Catalog No. ABIN731198

Product Details anti-SLC8A1 Antibody

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Binding Specificity: AA 801-900

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC8A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NCX1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SLC8A1

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Alternative Name: NCX1/SLC8A1 (SLC8A1 Products)

Synonyms: NCX1 antibody, AI852629 antibody, AV344025 antibody, D930008O12Rik antibody, Ncx1 antibody, Ncx antibody, SLC8A1 antibody, ncx1n antibody, solute carrier family 8 member A1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1b antibody, sodium/calcium exchanger 1 antibody, SLC8A1 antibody, Slc8a1 antibody, slc8a1b antibody, Tsp_07038 antibody

Background:

Synonyms: Na+/Ca2+exchanger 1, CNC, DKFZp779F0871, MGC119581 , FLJ37694, FLJ43417, Na+/Ca2+ exchange protein 1, Na+/Ca2+ exchanger, NCX 1, NCX, SLC8A1, SLC8A1 protein , Sodium Calcium Exchanger, Sodium/calcium exchanger 1, Solute carrier family 8 member 1.

Background: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma(plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM].

Gene ID: 6546

Pathways: Myometrial Relaxation and Contraction