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MMP8 antibody (AA 241-340)

MMP8 Reactivity: Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN736283
  • Target See all MMP8 Antibodies
    MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))
    Binding Specificity
    • 15
    • 10
    • 8
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 241-340
    Reactivity
    • 61
    • 33
    • 14
    • 1
    • 1
    Mouse
    Host
    • 75
    • 7
    Rabbit
    Clonality
    • 76
    • 6
    Polyclonal
    Conjugate
    • 33
    • 8
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MMP8 antibody is un-conjugated
    Application
    • 68
    • 33
    • 24
    • 11
    • 9
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MMP8
    Isotype
    IgG
    Top Product
    Discover our top product MMP8 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Sîrbulescu, Boehm, Soon, Wilks, Ilieş, Yuan, Maxner, Chronos, Kaittanis, Normandin, El Fakhri, Orgill, Sluder, Poznansky: "Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions." in: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, Vol. 25, Issue 5, pp. 774-791, (2018) (PubMed).

    Oralova, Matalova, Killinger, Knopfova, Smarda, Buchtova: "Osteogenic Potential of the Transcription Factor c-MYB." in: Calcified tissue international, Vol. 100, Issue 3, pp. 311-322, (2016) (PubMed).

    Zhang, Li, Zhang, Fu, Cui: "Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload." in: Acta pharmacologica Sinica, Vol. 34, Issue 10, pp. 1301-9, (2013) (PubMed).

  • Target
    MMP8 (Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8))
    Alternative Name
    MMP-8 (MMP8 Products)
    Synonyms
    MMP8 antibody, BB138268 antibody, CLG1 antibody, HNC antibody, MMP-8 antibody, PMNL-CL antibody, matrix metallopeptidase 8 antibody, neutrophil collagenase antibody, MMP8 antibody, Mmp8 antibody, LOC100339790 antibody
    Background

    Synonyms: HNC, CLG1, MMP-8, PMNL-CL, Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP8

    Background: Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.

    Gene ID
    4317
    UniProt
    P22894
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