Caspase 12 antibody (Caspase 12 (Gene/pseudogene)) (AA 240-290)

Details for Product anti-CASP12 Antibody No. ABIN737736, Supplier: Log in to see
Antigen
  • CASP-12
  • CASP12P1
  • caspase 12
  • caspase 12 (gene/pseudogene)
  • Casp12
  • CASP12
Alternatives
anti-Human Caspase 12 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 240-290
22
15
14
14
14
13
11
11
10
8
5
5
4
4
4
4
3
3
3
2
2
2
2
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
135
117
75
Host
Rabbit
169
16
12
Clonality
Polyclonal
Conjugate
This Caspase 12 antibody is un-conjugated
7
7
6
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
175
83
81
44
27
25
15
12
10
6
5
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen KLH conjugated synthetic peptide derived from mouse Caspase 12
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others Caspase 12 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Caspase 12 (CASP12 Antibody Abstract)
Background

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].

Subcellular location: Cytoplasm

Synonyms: Caspase-12, CASP-12, Casp12

Gene ID 12364
UniProt O08736
Pathways Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded protein response
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 240-290) antibody (ABIN737736) Formalin-fixed and paraffin embedded rat testis tissue (high fat) labeled with Anti-N...
ELISA image for anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 240-290) antibody (ABIN737736) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 240-290) antibody (ABIN737736) Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit Anti-Caspase 12 P...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 240-290) antibody (ABIN737736) Formalin-fixed and paraffin embedded rat testis tissue (high fat) labeled with Anti-N...
Western Blotting (WB) image for anti-Caspase 12 (Gene/pseudogene) (CASP12) (AA 240-290) antibody (ABIN737736) Lane 1: Mouse Cerebrum lysates Lane 2: Rat Cerebrum lysates probed with Caspase 12 Po...
Product cited in: Wang, Xuan, Cui, Wang, Chen, Wei, Zhao: "Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes." in: PLoS ONE, Vol. 12, Issue 4, pp. e0173469, 2017 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)).

Yu, Zhang, Zhao, Guo, Li, Li, Zhang, Sun: "Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 39, Issue 1, pp. 123-36, 2016 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: myocardial tissues

Wang, Wang, Huang, Yang, Zhao, Wei, Zhao: "Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways." in: Heart and vessels, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: myocardium of cardiomyopathy

Zhou, Zhou, Yu, Wu, Chen, Zhao et al.: "Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen ..." in: International journal of molecular medicine, Vol. 36, Issue 1, pp. 43-52, 2015 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Rat (Rattus)).

Zhang, Zhang, Lv, Jia, Fan, Tian, Li, Li, Ji, Wang, Zhao, Han, Ji: "Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis." in: International journal of clinical and experimental pathology, Vol. 8, Issue 8, pp. 9256-63, 2015 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: Liver

Zhang, Lv, Zhao, Jia, Zhang, Xiao, Wang, Li, Ji, Tian, Li, Fan, Lai, Liu, Li, Zhang, Liu, Guo, Han, Ji: "Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome." in: Gene, Vol. 545, Issue 1, pp. 156-62, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)). Further details: Sample: Lung

Did you look for something else?