MLXIPL antibody (AA 81-180)

Catalog No. ABIN747488

Product Details anti-MLXIPL Antibody

Target: MLXIPL (MLX Interacting Protein-Like (MLXIPL))

Binding Specificity: AA 81-180

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLXIPL antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WBSCR14/ChREBP

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MLXIPL

Target: MLXIPL (MLX Interacting Protein-Like (MLXIPL))

Alternative Name: WBSCR14 (MLXIPL Products)

Background:

Synonyms: ChREBP, bHLHd14, Carbohydrate responsive element binding protein, MIO, MLX interacting protein like, Mlx interactor, MLXIPL, MONDOB, WBSCR 14, WBSCR14, Williams Beuren syndrome chromosome region 14, Williams Beuren syndrome chromosome region 14 protein, WS basic helix loop helix leucine zipper protein, WS bHLH, MLXPL_HUMAN.

Background: ChREBP (Carbohydrate responsive element binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NLS) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine zipper like (zip-like) domain.ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney and white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol, translocating into the nucleus upon high glucose stimulation following its dephosphorylation of serine 196.

Gene ID: 51085

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process