CACNA1A antibody (AA 1401-1500) (HRP)

Catalog No. ABIN751312

Product Details anti-CACNA1A Antibody (HRP)

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Binding Specificity: AA 1401-1500

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1A antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CACNA1A

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CACNA1A

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Alternative Name: CACNA1A/Cav2.1 (CACNA1A Products)

Synonyms: cav2.1 antibody, cacna-a antibody, ca(v)2.1 antibody, cacna1a antibody, si:ch211-237k17.1 antibody, BccA1 antibody, Cav2.1 antibody, rbA-1 antibody, APCA antibody, BI antibody, CACNL1A4 antibody, CAV2.1 antibody, EA2 antibody, FHM antibody, HPCA antibody, MHP antibody, MHP1 antibody, SCA6 antibody, Caca1a antibody, Cacnl1a4 antibody, Ccha1a antibody, alpha1A antibody, la antibody, leaner antibody, nmf352 antibody, rkr antibody, rocker antibody, tg antibody, tottering antibody, CACH4 antibody, CACN3 antibody, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit S homeolog antibody, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a antibody, calcium voltage-gated channel subunit alpha1 A antibody, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit antibody, P/Q-type voltage-gated calcium channel alpha1A subunit ChCaChA1A antibody, cacna1a.S antibody, cacna1aa antibody, CACNA1A antibody, Cacna1a antibody, LOC395892 antibody

Background:

Synonyms: APCA, BI, Brain calcium channel 1, Brain calcium channel I, Cach4, Cacn3, Cacna1a, Cacnl1a4, Calcium channel alpha 1A subunit, Calcium channel L type alpha 1 polypeptide, Calcium channel L type alpha-1 polypeptide isoform 4, Calcium channel voltage dependent, P/Q type alpha 1A subunit, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, RAT brain class A, RBA-I, SCA6, Voltage-dependent P/Q-type calcium channel alpha-1A subunit, Voltage-gated calcium channel alpha subunit Cav2.1, CAC1A_HUMAN.

Background: Cav2.1 is a voltage-sensitive calcium channels (VSCC) which belongs to the calcium channel alpha-1 subunit family. Cav2.1 mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Cav2.1 (isoform alpha-1A) gives rise to P and/or Q-type calcium currents. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Gene ID: 773

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process