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ADAM11 antibody (AA 351-450) (Biotin)

ADAM11 Reactivity: Human, Mouse WB, ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN758743
  • Target See all ADAM11 Antibodies
    ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
    Binding Specificity
    • 14
    • 8
    • 7
    • 6
    • 2
    • 1
    AA 351-450
    Reactivity
    • 38
    • 21
    • 6
    • 5
    Human, Mouse
    Host
    • 36
    • 2
    Rabbit
    Clonality
    • 37
    • 1
    Polyclonal
    Conjugate
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADAM11 antibody is conjugated to Biotin
    Application
    • 37
    • 17
    • 13
    • 13
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Cow,Sheep
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ADAM11
    Isotype
    IgG
    Top Product
    Discover our top product ADAM11 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
    Alternative Name
    ADAM11 (ADAM11 Products)
    Synonyms
    DKFZp459F101 antibody, AW060611 antibody, Mdc antibody, MDC antibody, mdc antibody, mdc11a antibody, xMDC11 antibody, ADAM metallopeptidase domain 11 antibody, a disintegrin and metallopeptidase domain 11 antibody, ADAM metallopeptidase domain 11 L homeolog antibody, ADAM11 antibody, adam11 antibody, Adam11 antibody, adam11.L antibody
    Background

    Synonyms: A disintegrin and metalloproteinase domain 11, ADA11_HUMAN, MDC, Metalloproteinase like, disintegrin like, and cysteine rich protein.

    Background: ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.

    Gene ID
    4185
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