GSAP antibody (C-Term)

Catalog No. ABIN783371

Product Details anti-GSAP Antibody

Target: GSAP (PION) (Pigeon Homolog (PION))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSAP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects PION at C-term. Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human PION

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for GSAP

Target: GSAP (PION) (Pigeon Homolog (PION))

Alternative Name: PION / GSAP (PION Products)

Background: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer s disease. The β-amyloid protein precursor (APP) is cleaved by one of two β-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ?secretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog

Gene ID: 54103

NCBI Accession: NP_059135

UniProt: A4D1B5