ZIP2 antibody (N-Term)

Catalog No. ABIN783797

Product Details anti-ZIP2 Antibody

Target: ZIP2 (Slc39a2) (Solute Carrier Family 39 (Zinc Transporter), Member 2 (Slc39a2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZIP2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Zinc transporter ZIP2 / SLC39A2 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide near the amino terminus of human ZIP2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for ZIP2

Target: ZIP2 (Slc39a2) (Solute Carrier Family 39 (Zinc Transporter), Member 2 (Slc39a2))

Alternative Name: Zinc Transporter ZIP2 / SLC39A2 (Slc39a2 Products)

Background: The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.Synonyms: Eti-1, Solute carrier family 39 member 2, ZIP-2, ZIP2, Zrt- and Irt-like protein 2

Gene ID: 29986

NCBI Accession: NP_055394

UniProt: Q9NP94

Pathways: Autophagy