TWIST2 antibody (AA 26-30)

Catalog No. ABIN871769

Product Details anti-TWIST2 Antibody

Target: TWIST2 (Twist Homolog 2 (TWIST2))

Binding Specificity: AA 26-30

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWIST2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: The antibody detects endogenous level of total Twist2 protein.

Purification: Affinity purified

Immunogen: Peptide sequence around AA 26-30 (P-K-R-F-G) derived from Human Twist2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Application Details

Application Notes: Western blotting 1:100-1:500
Immunohistochemistry  1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for TWIST2

Target: TWIST2 (Twist Homolog 2 (TWIST2))

Alternative Name: Twist2 (TWIST2 Products)

Synonyms: TWIST2 antibody, DERMO1 antibody, FFDD3 antibody, SETLSS antibody, bHLHa39 antibody, Dermo1 antibody, CDERMO-1 antibody, twist family bHLH transcription factor 2 antibody, twist basic helix-loop-helix transcription factor 2 antibody, TWIST2 antibody, Twist2 antibody

Background: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

Gene ID: 117581

NCBI Accession: NP_476527

UniProt: Q8WVJ9

Pathways: Chromatin Binding