Charged Multivesicular Body Protein 1A (CHMP1A) (AA 1-50) antibody

Details for Product No. ABIN872527, Supplier: Log in to see
Antigen
  • CHMP1
  • PCH8
  • PCOLN3
  • PRSM1
  • VPS46-1
  • VPS46A
  • 2900018H07Rik
  • Pcoln3
  • charged multivesicular body protein 1A
  • CHMP1A
  • Chmp1a
Epitope
AA 1-50
12
10
9
7
5
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
48
13
5
Host
Rabbit
41
6
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
42
27
9
4
2
1
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human CHMP1A
Isotype IgG
Purification Purified by Protein A.
Alternative Name Chmp1a (CHMP1A Antibody Abstract)
Background

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Subcellular location: Cytoplasm, Nucleus

Synonyms: PCH8, CHMP1, PRSM1, PCOLN3, VPS46A, VPS46-1, Charged multivesicular body protein 1a, Chromatin-modifying protein 1a, CHMP1a, Vacuolar protein sorting-associated protein 46-1, hVps46-1, KIAA0047

Gene ID 5119
UniProt Q9HD42
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Charged Multivesicular Body Protein 1A (CHMP1A) (AA 1-50) antibody (ABIN872527) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti CH...
Immunohistochemistry (IHC) image for anti-Charged Multivesicular Body Protein 1A (CHMP1A) (AA 1-50) antibody (ABIN872527) Formalin-fixed and paraffin embedded human placenta labeled with Rabbit Anti CHMP1A P...
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