APEX2 antibody (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2) (Alexa Fluor 350)

Details for Product anti-APEX2 Antibody No. ABIN882988
Antigen
  • APE2
  • APEXL2
  • XTH2
  • ape2
  • apexl2
  • xth2
  • zgc:55889
  • C430040P13Rik
  • apurinic/apyrimidinic endodeoxyribonuclease 2
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog
  • apurinic/apyrimidinic endonuclease 2
  • APEX2
  • apex2
  • apex2.L
  • Apex2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
48
15
14
Host
Rabbit
46
3
Clonality
Polyclonal
Conjugate
This APEX2 antibody is conjugated to Alexa Fluor 350
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
34
23
18
12
8
5
4
1
Options
Immunogen KLH conjugated synthetic peptide derived from human APEX2
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others APEX2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name APEX2 (APEX2 Antibody Abstract)
Background

Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

Subcellular location: Cytoplasm, Nucleus, Mitochondrion

Synonyms: APE2, XTH2, ZGRF2, APEXL2, DNA-(apurinic or apyrimidinic site) lyase 2, AP endonuclease XTH2, APEX nuclease 2, APEX nuclease-like 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2, APEX2

Gene ID 27301
UniProt Q9UBZ4
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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