BRE antibody (AA 301-383) (Alexa Fluor 350)

Catalog No. ABIN885476

Product Details anti-BRE Antibody (Alexa Fluor 350)

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Binding Specificity: AA 301-383

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRE antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BRCC45

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BRE

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Alternative Name: BRCC45 (BRE Products)

Synonyms: brcc4 antibody, brcc45 antibody, BRE antibody, LOC100231620 antibody, BRCC4 antibody, BRCC45 antibody, 6030405P19Rik antibody, AI429776 antibody, B830038C02Rik antibody, im:7141046 antibody, zgc:110368 antibody, BRISC and BRCA1 A complex member 2 antibody, brain and reproductive organ-expressed (TNFRSF1A modulator) antibody, BRISC and BRCA1 A complex member 2 L homeolog antibody, babam2 antibody, BABAM2 antibody, Babam2 antibody, BRE antibody, babam2.L antibody

Background:

Synonyms: Brain and reproductive organ expressed TNFRSF1A modulator, BRCA1/BRCA2 containing complex subunit 4, BRCA1/BRCA2 containing complex subunit 45, BRCC4, BRCC45, BRE_HUMAN.

Background: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Gene ID: 9577

Pathways: Positive Regulation of Response to DNA Damage Stimulus