CDC14B antibody (AA 65-160) (HRP)

Catalog No. ABIN889453

Product Details anti-CDC14B Antibody (HRP)

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Binding Specificity: AA 65-160

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC14B antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDC14B

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CDC14B

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Alternative Name: CDC14B (CDC14B Products)

Synonyms: CDC14B antibody, 2810432N10Rik antibody, A530086E13Rik antibody, AA472821 antibody, CDC14B3 antibody, Cdc14B1 antibody, Cdc14B2 antibody, hCDC14B antibody, Dual specificity protein phosphatase CDC14B antibody, dual specificity protein phosphatase CDC14B antibody, cell division cycle 14B antibody, CDC14 cell division cycle 14B antibody, Bm1_19115 antibody, LOAG_10083 antibody, CDC14B antibody, cdc14b antibody, Cdc14b antibody

Background:

Synonyms: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B, Dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B, CDC14B

Background: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Gene ID: 8555

UniProt: O60729