Granzyme D/B/E/N/G/F/H antibody (Alexa Fluor 555)

Catalog No. ABIN899666

Product Details

Target: Granzyme D/B/E/N/G/F/H

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 555

Application: Western Blotting (WB)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Granzyme D/B/E/N/G/F/H

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Granzyme D/B/E/N/G/F/H

Sub Type: Cocktail

Background:

Synonyms: Granzyme D, Granzyme B, Granzyme E, Granzyme N, Granzyme G, Granzyme F, Granzyme H, Cathepsin G-like 2, CCP-X, CCP3, CCP4, CCP5, CGL-2, CSP-C, Ctla-5, Ctla-6, Ctla-7, CTLA1, CTSGL2, Grz d, Grz e, Grz f, Grz g, GZMD, Gzme, Gzmf, Gzmg, GZMH, MCSP-2, MCSP-3, MGC117682, Rnkp7, mast cell proteinase-3-like, Cytotoxic T-lymphocyte proteinase, Granzyme H precursor, Cytotoxic serine protease-C, CSP-C.

Background: protease required for lymphocyte cytotoxic granules to lyse target cells [RGD]. Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.

Gene ID: 2999