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PIDD antibody (AA 551-650) (Alexa Fluor 647)

PIDD Reactivity: Rat IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 647
Catalog No. ABIN905080
  • Target See all PIDD Antibodies
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Binding Specificity
    • 14
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 551-650
    Reactivity
    • 20
    • 19
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 33
    • 3
    Rabbit
    Clonality
    • 33
    • 3
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIDD antibody is conjugated to Alexa Fluor 647
    Application
    • 14
    • 12
    • 12
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human LRDD/PIDD
    Isotype
    IgG
    Top Product
    Discover our top product PIDD Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Alternative Name
    LRDD (PIDD Products)
    Synonyms
    1200011D09Rik antibody, AU042446 antibody, Pidd antibody, LRDD antibody, Lrdd antibody, p53 induced death domain protein 1 antibody, p53-induced death domain protein 1 antibody, Pidd1 antibody, PIDD1 antibody
    Background

    Synonyms: Leucine rich repeats and death domain containing, Leucine-rich repeats and death domain containing, MGC16925, p53-induced protein with a death domain, PIDD, DKFZp434D229, PIDD_HUMAN.

    Background: The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.

    Pathways
    p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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