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Prominin 2 antibody (AA 301-400) (Alexa Fluor 647)

PROM2 Reactivity: Human WB, FACS, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 647
Catalog No. ABIN912237
  • Target See all Prominin 2 (PROM2) Antibodies
    Prominin 2 (PROM2)
    Binding Specificity
    • 15
    • 8
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    AA 301-400
    Reactivity
    • 38
    • 5
    • 4
    • 1
    • 1
    Human
    Host
    • 37
    • 1
    Rabbit
    Clonality
    • 37
    • 1
    Polyclonal
    Conjugate
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Prominin 2 antibody is conjugated to Alexa Fluor 647
    Application
    • 35
    • 20
    • 13
    • 12
    • 12
    • 5
    • 5
    • 4
    • 3
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Pig
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Prominin 2
    Isotype
    IgG
    Top Product
    Discover our top product PROM2 Primary Antibody
  • Application Notes
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Prominin 2 (PROM2)
    Alternative Name
    Prominin 2 (PROM2 Products)
    Synonyms
    PROML2 antibody, Prom-rp antibody, Promrp antibody, Trprp antibody, AI507243 antibody, PROM2 antibody, prom3 antibody, proml3 antibody, fd36c02 antibody, fo25d03 antibody, wu:fd36c02 antibody, prom-2 antibody, prominin 2 antibody, prominin 2 L homeolog antibody, PROM2 antibody, Prom2 antibody, prom2 antibody, prom2.L antibody
    Background

    Synonyms: PROML2, Prominin-2, PROM-2, Prominin-like protein 2, hPROML2, PROM2, UNQ2521/PRO6014

    Background: Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30 % , but their genomic organization is strikingly similar. Like Prominin 1, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains. Similar to Prominin1 localization, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from adult kidney, and all along the digestive track and other epithelial tissues.Prominin 2 expression is down-regulated in aggressive prostate cancer cell lines and transient transfection of PROML2 expression vectors has been shown to induce apoptosis in cultured prostate cancer cells, suggesting a tumor suppressive role for Prominin 2. Prominin 2 expression is likely to be involved in growth suppression in the prostate, and down-regulation of Prominin 2 may disrupt normal prostatic homeostasis and lead to uncontrolled prostatic growth.

    Gene ID
    150696
    UniProt
    Q8N271
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