RBM38 antibody (AA 51-150) (Alexa Fluor 350)

Catalog No. ABIN913173

Product Details anti-RBM38 Antibody (Alexa Fluor 350)

Target: RBM38 (RNA Binding Motif Protein 38 (RBM38))

Binding Specificity: AA 51-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM38 antibody is conjugated to Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RBM38

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RBM38

Target: RBM38 (RNA Binding Motif Protein 38 (RBM38))

Alternative Name: RBM38 (RBM38 Products)

Synonyms: rnpc1 antibody, seb4b antibody, seb4d antibody, XSeb4R antibody, MGC89204 antibody, hsrnaseb antibody, YF-55 antibody, fi25e12 antibody, wu:fi25e12 antibody, zgc:92336 antibody, xseb4r antibody, HSRNASEB antibody, RNPC1 antibody, SEB4B antibody, SEB4D antibody, dJ800J21.2 antibody, Rnpc1 antibody, Seb4 antibody, Seb4l antibody, RNA binding motif protein 38 antibody, RNA binding motif protein 38 L homeolog antibody, rbm38 antibody, rbm38.L antibody, RBM38 antibody, Rbm38 antibody

Background:

Synonyms: SEB4D, CLL associated antigen KW 5, CLL-associated antigen KW-5, HSRNASEB, RBM38, RBM38_HUMAN, RNA binding mot protein 38, RNA binding protein 38, RNA binding region RNP1, RRM containing 1, RNA binding region containing protein 1, RNA-binding mot protein 38, RNA-binding protein 38, RNA-binding region-containing protein 1, RNPC1, SEB4, SEB4B, ssDNA binding protein SEB4, ssDNA-binding protein SEB4.

Background: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.

Gene ID: 55544

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development