MAFK antibody (N-Term)

Catalog No. ABIN925961

Product Details anti-MAFK Antibody

Target: MAFK (Transcription Factor MafK (MAFK))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAFK antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Dog (Canine), Chicken, Frog, Zebrafish (Brachydanio rerio), Cow (Bovine)

Immunogen: MAFK antibody was raised in rabbit using the N terminal of MAFK as the immunogen

Application Details

Application Notes: WB: 2.5 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

MAFK Blocking Peptide, catalog no. 33R-4314, is also available for use as a blocking control in assays to test for specificity of this MAFK antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for MAFK

Target: MAFK (Transcription Factor MafK (MAFK))

Alternative Name: MAFK (MAFK Products)

Synonyms: NFE2U antibody, P18 antibody, AW061068 antibody, NF-E2 antibody, Nfe2u antibody, MAF bZIP transcription factor K antibody, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K antibody, Mafk antibody, MAFK antibody, mafk antibody

Background: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2. NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, PBGD and FECH. NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG, or MafK) and p45. Both subunits are members of the activator protein-1 superfamily of bZIP proteins. Maf homodimers suppress transcription at NFE2 sites. Synonyms: Polyclonal MAFK antibody, Anti-MAFK antibody, v-maf musculoaponeurotic fibrosarcoma oncogene homolog K, avian antibody, FLJ32205 antibody, MGC71717 antibody, NFE2U antibody, P18 antibody.