SH2D1A antibody (C-Term)

Catalog No. ABIN926473

Product Details anti-SH2D1A Antibody

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH2D1A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: SH2 D2 antibody was raised in rabbit using the C terminal of SH2 2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

SH2D1A Blocking Peptide, catalog no. 33R-10098, is also available for use as a blocking control in assays to test for specificity of this SH2D1A antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Alternative Name: SH2D1A (SH2D1A Products)

Synonyms: DSHP antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, XLP antibody, XLPD antibody, RGD1562408 antibody, Gm686 antibody, SH2D1A antibody, SH2 domain containing 1A antibody, SH2D1A antibody, Sh2d1a antibody

Background: SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Synonyms: Polyclonal SH2D1A antibody, Anti-SH2D1A antibody, SH2 domain protein 1A antibody, DSHP antibody, EBVS antibody, FLJ18687 antibody, FLJ92177 antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, XLP antibody, XLPD antibody.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process