HARS1/Jo-1 antibody (N-Term)

Catalog No. ABIN926720

Product Details anti-HARS1/Jo-1 Antibody

Target: HARS1/Jo-1 (HARS1) (Histidyl-tRNA Synthetase (HARS1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HARS1/Jo-1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: HARS antibody was raised in rabbit using the N terminal of HARS as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

HARS Blocking Peptide, catalog no. 33R-3116, is also available for use as a blocking control in assays to test for specificity of this HARS antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for HARS1/Jo-1

Target: HARS1/Jo-1 (HARS1) (Histidyl-tRNA Synthetase (HARS1))

Alternative Name: HARS (HARS1 Products)

Synonyms: HRS antibody, USH3B antibody, MMHRS antibody, Dnd1 antibody, HARSL antibody, histidyl-tRNA synthetase antibody, HARS antibody, Hars antibody

Background: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Synonyms: Polyclonal HARS antibody, Anti-HARS antibody, histidyl-tRNA synthetase antibody, FLJ20491 antibody, HRS antibody.