PRKAR2A antibody (Middle Region)

Catalog No. ABIN926761

Product Details anti-PRKAR2A Antibody

Target: PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKAR2A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: PRKAR2 A antibody was raised in rabbit using the middle region of PRKAR2 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

PRKAR2A Blocking Peptide, catalog no. 33R-2001, is also available for use as a blocking control in assays to test for specificity of this PRKAR2A antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PRKAR2A

Target: PRKAR2A (Protein Kinase, CAMP-Dependent, Regulatory, Type II, alpha (PRKAR2A))

Alternative Name: PRKAR2A (PRKAR2A Products)

Synonyms: PKR2 antibody, PRKAR2 antibody, prkar2a antibody, zgc:85886 antibody, PRKAR2A antibody, 1110061A24Rik antibody, AI317181 antibody, AI836829 antibody, RII(alpha) antibody, protein kinase cAMP-dependent type II regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha, B antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha antibody, protein kinase, cAMP dependent regulatory, type II alpha antibody, protein kinase cAMP-dependent type 2 regulatory subunit alpha antibody, PRKAR2A antibody, prkar2ab antibody, Prkar2a antibody

Background: CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). Synonyms: Polyclonal PRKAR2A antibody, Anti-PRKAR2A antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha antibody, MGC3606 antibody, PKR2 antibody, PRKAR2 antibody.

Pathways: Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection