CIITA antibody (C-Term)

Catalog No. ABIN927649

Product Details anti-CIITA Antibody

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Binding Specificity: C-Term

Reactivity: Mouse, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIITA antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Rat (Rattus), Dog (Canine)

Purification: Purified

Immunogen: C2 TA antibody was raised in rabbit using the C terminal of C2 A as the immunogen

Application Details

Application Notes: WB: 0.125 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

C2TA Blocking Peptide, catalog no. 33R-5700, is also available for use as a blocking control in assays to test for specificity of this C2TA antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for CIITA

Target: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Alternative Name: C2TA (CIITA Products)

Synonyms: CIITA antibody, C2ta antibody, EG669998 antibody, Gm9475 antibody, C2TA antibody, CIITAIV antibody, MHC2TA antibody, NLRA antibody, Mhc2ta antibody, class II, major histocompatibility complex, transactivator antibody, class II major histocompatibility complex transactivator antibody, MHC class II transactivator antibody, class II transactivator antibody, CIITA antibody, LOC710761 antibody, ciita antibody, LOC100443575 antibody, Ciita antibody, LOC100736732 antibody

Background: C2ta is essential for transcriptional activity of the HLA class II promoter, activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. C2ta may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Synonyms: Polyclonal C2TA antibody, Anti-C2TA antibody.

Pathways: Cancer Immune Checkpoints