Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

FZR1 antibody (N-Term)

FZR1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN928538
  • Target See all FZR1 Antibodies
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Binding Specificity
    • 15
    • 10
    • 8
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 57
    • 31
    • 15
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 51
    • 6
    Rabbit
    Clonality
    • 51
    • 6
    Polyclonal
    Conjugate
    • 22
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FZR1 antibody is un-conjugated
    Application
    • 45
    • 23
    • 13
    • 13
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Mouse (Murine)
    Purification
    Purified
    Immunogen
    Fzr1 antibody was raised in rabbit using the N terminal of Fzr1 as the immunogen
    Top Product
    Discover our top product FZR1 Primary Antibody
  • Application Notes
    WB: 0.2-1 µg/mL
    Optimal conditions should be determined by the investigator.
    Comment

    Fzr1 Blocking Peptide, catalog no. 33R-8121, is also available for use as a blocking control in assays to test for specificity of this Fzr1 antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
  • Target
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Alternative Name
    Fzr1 (FZR1 Products)
    Synonyms
    CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
    Background
    Fzr1 is the key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Fzr1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Synonyms: Polyclonal Fzr1 antibody, Anti-Fzr1 antibody, fizzy/cell division cycle 20 related 1, Drosophila antibody, AW108046 antibody, Cdh1 antibody, FZR antibody, FZR2 antibody, Fyr antibody, HCDH antibody, HCDH1 antibody.
    Pathways
    DNA Replication, Synthesis of DNA
You are here:
Support