BNIP3L/NIX antibody (Middle Region)

Catalog No. ABIN929075

Product Details anti-BNIP3L/NIX Antibody

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Binding Specificity: Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BNIP3L/NIX antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: Bnip3 l antibody was raised in rabbit using the middle region of Bnip3 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

Bnip3l Blocking Peptide, catalog no. 33R-1671, is also available for use as a blocking control in assays to test for specificity of this Bnip3l antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Alternative Name: Bnip3l (BNIP3L Products)

Synonyms: BNIP3a antibody, NIX antibody, NIP3 antibody, Nix antibody, Nip3 antibody, C86132 antibody, D14Ertd719e antibody, Nip3L antibody, bnip3l antibody, nip3 antibody, zgc:110478 antibody, bnip3l2 antibody, wu:fb52b03 antibody, wu:fc02h04 antibody, BCL2 interacting protein 3 like antibody, BCL2 interacting protein 3 antibody, BCL2/adenovirus E1B interacting protein 3 antibody, BCL2/adenovirus E1B interacting protein 3-like antibody, BCL2/adenovirus E1B interacting protein 3-like b antibody, BCL2/adenovirus E1B interacting protein 3-like a antibody, BNIP3L antibody, BNIP3 antibody, Bnip3l antibody, Bnip3 antibody, bnip3lb antibody, bnip3la antibody

Background: Bnip3l induces apoptosis. It interacts with viral and cellular anti-apoptosis proteins. It can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. It inhibits apoptosis induced by BNIP3. It is involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. Bnip3l may function as a tumor suppressor. Synonyms: Polyclonal Bnip3l antibody, Anti-Bnip3l antibody, BCL2/adenovirus E1B interacting protein 3-like antibody, C86132 antibody, D14Ertd719e antibody, Nip3L antibody, Nix antibody.

Pathways: Autophagy