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Presenilin 1 antibody (Middle Region)

PSEN1 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN929092
  • Target See all Presenilin 1 (PSEN1) Antibodies
    Presenilin 1 (PSEN1)
    Binding Specificity
    • 31
    • 15
    • 15
    • 13
    • 11
    • 11
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 123
    • 101
    • 66
    • 9
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 111
    • 36
    • 2
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 145
    • 8
    Polyclonal
    Conjugate
    • 49
    • 12
    • 12
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    This Presenilin 1 antibody is un-conjugated
    Application
    • 122
    • 56
    • 55
    • 52
    • 52
    • 18
    • 15
    • 13
    • 11
    • 8
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Purification
    Purified
    Immunogen
    PSEN1 antibody was raised in rabbit using the middle region of PSEN1 as the immunogen
    Top Product
    Discover our top product PSEN1 Primary Antibody
  • Application Notes
    WB: 0.2-1 µg/mL
    Optimal conditions should be determined by the investigator.
    Comment

    PSEN1 Blocking Peptide, catalog no. 33R-2422, is also available for use as a blocking control in assays to test for specificity of this PSEN1 antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
  • Target
    Presenilin 1 (PSEN1)
    Alternative Name
    PSEN1 (PSEN1 Products)
    Synonyms
    pre1 antibody, psen antibody, zfPS1 antibody, zf-PS1 antibody, ad3 antibody, fad antibody, ps1 antibody, s182 antibody, X-PS-beta antibody, X-PS-alpha antibody, AD3 antibody, FAD antibody, PS-1 antibody, PS1 antibody, S182 antibody, Ad3h antibody, presenilin 1 antibody, presenilin 1 L homeolog antibody, psen1 antibody, PSEN1 antibody, Psen1 antibody, psen1.L antibody
    Background
    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Synonyms: Polyclonal PSEN1 antibody, Anti-PSEN1 antibody, presenilin 1 antibody, AD3 antibody, FAD antibody, PS1 antibody, S182 antibody.
    Pathways
    Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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