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USP20 antibody (Middle Region)

USP20 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN929196
  • Target See all USP20 Antibodies
    USP20 (Ubiquitin Specific Peptidase 20 (USP20))
    Binding Specificity
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 42
    • 12
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 38
    • 4
    • 1
    Rabbit
    Clonality
    • 42
    • 1
    Polyclonal
    Conjugate
    • 22
    • 5
    • 4
    • 4
    • 4
    • 4
    This USP20 antibody is un-conjugated
    Application
    • 30
    • 26
    • 17
    • 4
    • 4
    Western Blotting (WB)
    Purification
    Purified
    Immunogen
    USP20 antibody was raised in rabbit using the middle region of USP20 as the immunogen
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    Discover our top product USP20 Primary Antibody
  • Application Notes
    WB: 0.2-1 µg/mL
    Optimal conditions should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Concentration
    Lot specific
    Buffer
    Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
  • Target
    USP20 (Ubiquitin Specific Peptidase 20 (USP20))
    Alternative Name
    USP20 (USP20 Products)
    Synonyms
    USP20 antibody, vdu2 antibody, lsfr3a antibody, LSFR3A antibody, VDU2 antibody, hVDU2 antibody, 1700055M05Rik antibody, AI467231 antibody, Vdu2 antibody, im:7151955 antibody, zgc:63661 antibody, universal stress protein antibody, ubiquitin specific peptidase 20 antibody, ubiquitin specific peptidase 20 L homeolog antibody, RR_RS15875 antibody, USP20 antibody, usp20 antibody, Usp20 antibody, usp20.L antibody
    Background
    USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Synonyms: Polyclonal USP20 antibody, Anti-USP20 antibody, ubiquitin specific peptidase 20 antibody, KIAA1003 antibody, LSFR3A antibody, VDU2 antibody.
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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