USP20 antibody (Middle Region)
-
- Target See all USP20 Antibodies
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
-
Binding Specificity
- Middle Region
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This USP20 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Purification
- Purified
- Immunogen
- USP20 antibody was raised in rabbit using the middle region of USP20 as the immunogen
- Top Product
- Discover our top product USP20 Primary Antibody
-
-
- Application Notes
-
WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator. - Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
-
- Target
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Alternative Name
- USP20 (USP20 Products)
- Synonyms
- USP20 antibody, vdu2 antibody, lsfr3a antibody, LSFR3A antibody, VDU2 antibody, hVDU2 antibody, 1700055M05Rik antibody, AI467231 antibody, Vdu2 antibody, im:7151955 antibody, zgc:63661 antibody, universal stress protein antibody, ubiquitin specific peptidase 20 antibody, ubiquitin specific peptidase 20 L homeolog antibody, RR_RS15875 antibody, USP20 antibody, usp20 antibody, Usp20 antibody, usp20.L antibody
- Background
- USP20 is a deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling.USP20 acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). USP20 plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Synonyms: Polyclonal USP20 antibody, Anti-USP20 antibody, ubiquitin specific peptidase 20 antibody, KIAA1003 antibody, LSFR3A antibody, VDU2 antibody.
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
-