PEN2 antibody (N-Term)

Catalog No. ABIN929231

Product Details anti-PEN2 Antibody

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse (Murine)

Purification: Purified

Immunogen: Psenen antibody was raised in rabbit using the N terminal of Psenen as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

Psenen Blocking Peptide, catalog no. 33R-4973, is also available for use as a blocking control in assays to test for specificity of this Psenen antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: Psenen (PSENEN Products)

Synonyms: MSTP064 antibody, PEN-2 antibody, PEN2 antibody, Psenen antibody, ACYPI006208 antibody, 1700023M09Rik antibody, Pen-2 antibody, RGD1312037 antibody, CG33198 antibody, Dmel\\CG33198 antibody, anon-AE003800.1 antibody, dPen-2 antibody, psenen antibody, pen-2 antibody, pen2 antibody, zgc:109727 antibody, presenilin enhancer gamma-secretase subunit antibody, presenilin enhancer 2 antibody, presenilin enhancer gamma secretase subunit antibody, Gamma-secretase subunit pen-2 antibody, presenilin enhancer antibody, presenilin enhancer gamma secretase subunit S homeolog antibody, PSENEN antibody, PEN2 antibody, Psenen antibody, pen-2 antibody, psenen.S antibody, psenen antibody

Background: Psenen is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Synonyms: Polyclonal Psenen antibody, Anti-Psenen antibody, presenilin enhancer 2 homolog, C. elegans antibody, 1700023M09Rik antibody, MGC102026 antibody.

Pathways: Notch Signaling, Neurotrophin Signaling Pathway