CBFB antibody

Catalog No. ABIN931127

Product Details anti-CBFB Antibody

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBFB antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Dot Blot (DB)

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: CBFB antibody was raised in mouse using recombinant Human Core-Binding Factor, Beta Subunit

Clone: 344C3a

Isotype: IgG1

Application Details

Application Notes: WB: 0.2-2 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: CBFB antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for CBFB

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Alternative Name: CBFB (CBFB Products)

Synonyms: PEBP2B antibody, Cbfb antibody, pebp2b antibody, Pebp2 antibody, CBFB antibody, unp1266 antibody, cbf-beta antibody, cbfbeta antibody, pea2-beta antibody, pebp2-beta antibody, AI893578 antibody, PEA2 antibody, PEBP2b antibody, Pebpb2 antibody, core-binding factor beta subunit antibody, core binding factor beta subunit antibody, core-binding factor, beta subunit antibody, core-binding factor, beta subunit S homeolog antibody, core binding factor beta antibody, CBFB antibody, Cbfb antibody, cbfb antibody, cbfb.S antibody

Background: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Synonyms: Monoclonal CBFB antibody, Anti-CBFB antibody, Core-binding factor subunit beta antibody, PEBP2B antibody.

Pathways: Regulation of Lipid Metabolism by PPARalpha