Calcineurin B antibody

Catalog No. ABIN933160

Product Details anti-Calcineurin B Antibody

Target: Calcineurin B (CAN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Calcineurin B antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Sterility: Filtered

Immunogen: Calcineurin B antibody was raised in mouse using E. coli-derived recombinant human calcineurin B as the immunogen.

Clone: 323417

Isotype: IgG2a

Application Details

Application Notes: WB: 0.5 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with sterile PBS.

Concentration: Lot specific

Buffer: Lyophilized from a 0.2 µm filtered solution in PBS with 5 % trehalose.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Target Details for Calcineurin B

Target: Calcineurin B (CAN)

Alternative Name: Calcineurin B (CAN Products)

Synonyms: PPP3RL antibody, BcDNA:RH11383 antibody, CG4209 antibody, CNB antibody, Can antibody, CnB antibody, Dmel\\CG4209 antibody, canB-4F antibody, dCnB1 antibody, Cnb antibody, Cblp antibody, CaNB2 antibody, protein phosphatase 3 regulatory subunit B, beta antibody, Calcineurin B antibody, calcineurin B antibody, protein phosphatase 3, regulatory subunit B, beta antibody, protein phosphatase 3 regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) antibody, PPP3R2 antibody, CanB antibody, Cnb antibody, Ppp3r2 antibody, PPP3R1 antibody

Background: Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes ciclosporin, pimecrolimus and tacrolimus. Synonyms: Monoclonal Calcineurin B antibody, Anti-Calcineurin B antibody.

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling