Allopregnanolone antibody

Details for Product No. ABIN93544
Antigen
Reactivity
Hormone
3
1
1
1
Host
Chicken
5
2
Clonality
Polyclonal
Application
Radioimmunoassay (RIA)
5
3
3
2
2
2
2
1
1
1
Options
Immunogen BSA conjugated-allopregnanolone
Isotype IgY
Predicted Reactivity not applicable
Purification affinity purified
Antigen
Target Type Hormone
Background Allopregnanolone, (3alpha-hydroxy-5alpha-pregnan-20-ol), also known as 3alpha,5alpha-tetrahydroprogesterone or THP, is a neuroactive steroid secreted by the mammalian ovary and adrenal. It exerts its anesthetic, anxiolytic, and sedative/hypnotic effects through potentiation of GABA A receptors and its release is stimulated by trophic hormones in relation to stress and reproductive hormone secretion.
Application Notes 1: 1000 (RIA)
Restrictions For Research Use only
Format Liquid
Buffer PBS pH 8.0 + 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Make aliquots to avoid repreated freeze-thaw cycles and working with a stock.
Storage 4 °C
Storage Comment store at 4°C, make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Product cited in: Evans, Sun, McGregor, Connor: "Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress." in: Neuropharmacology, Vol. 63, Issue 8, pp. 1315-26, 2012 (PubMed).