ABCD1 antibody (Middle Region)

Catalog No. ABIN950202

This anti-ABCD1 antibody is a Rabbit Polyclonal antibody detecting ABCD1 in WB, IHC (p) and EIA. Suitable for Human.

Quick Overview for ABCD1 antibody (Middle Region) (ABIN950202)

Target: ABCD1 (ATP-Binding Cassette, Sub-Family D (Ald), Member 1 (ABCD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-ABCD1 Antibody

Binding Specificity: AA 264-293, Middle Region

Specificity: This antibody reacts to ABCD1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 264-293 amino acids from the Central region of human ABCD1.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ABCD1

Target: ABCD1 (ATP-Binding Cassette, Sub-Family D (Ald), Member 1 (ABCD1))

Alternative Name: ABCD1 / ALDP

Background: ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.Synonyms: ATP-binding cassette sub-family D member 1

Gene ID: 215

NCBI Accession: NP_000024

Pathways: Monocarboxylic Acid Catabolic Process