AKR1C2 antibody (C-Term)

Catalog No. ABIN950320

Product Details anti-AKR1C2 Antibody

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Binding Specificity: AA 295-323, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1C2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to AKR1C2.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 295-323 amino acids from the C-terminal region of human AKR1C2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AKR1C2

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Alternative Name: AKR1C2 / DDH2 (AKR1C2 Products)

Synonyms: AKR1C-pseudo antibody, BABP antibody, DD antibody, DD2 antibody, DDH2 antibody, HAKRD antibody, HBAB antibody, MCDR2 antibody, SRXY8 antibody, Akr1c21 antibody, aldo-keto reductase family 1 member C2 antibody, aldo-keto reductase family 1, member C2 antibody, AKR1C2 antibody, Akr1c2 antibody

Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.Synonyms: 2-dihydrobenzene-1, 2-diol dehydrogenase, 3-alpha-HSD3, Aldo-keto reductase family 1 member C2, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, Dihydrodiol dehydrogenase/bile acid-binding protein, Trans-1, Type III 3-alpha-hydroxysteroid dehydrogenase

Molecular Weight: 36735 Da

Gene ID: 1646

NCBI Accession: NP_001345

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process