AKR1D1 antibody (Middle Region)

Catalog No. ABIN950324

Product Details anti-AKR1D1 Antibody

Target: AKR1D1 (Aldo-Keto Reductase Family 1, Member D1 (AKR1D1))

Binding Specificity: AA 110-139, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKR1D1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to AKR1D1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 110-139 amino acids from the Central region of human AKR1D1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AKR1D1

Target: AKR1D1 (Aldo-Keto Reductase Family 1, Member D1 (AKR1D1))

Alternative Name: AKR1D1 / SRD5B1 (AKR1D1 Products)

Synonyms: 3o5bred antibody, CBAS2 antibody, SRD5B1 antibody, 3-oxo-5-beta-steroid 4-dehydrogenase-like antibody, aldo-keto reductase family 1 member D1 antibody, aldo-keto reductase family 1, member D1 antibody, aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) antibody, LOC491379 antibody, AKR1D1 antibody, Akr1d1 antibody

Background: The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.Synonyms: 3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase

Gene ID: 6718

NCBI Accession: NP_005980

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process