ARHGEF6 antibody (C-Term)

Catalog No. ABIN950497

Product Details anti-ARHGEF6 Antibody

Target: ARHGEF6 (rho Guanine Nucleotide Exchange Factor (GEF) 6 (ARHGEF6))

Binding Specificity: AA 613-641, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF6 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to ARHGEF6.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 613-641 amino acids from the C-terminal region of human ARHGEF6

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ARHGEF6

Target: ARHGEF6 (rho Guanine Nucleotide Exchange Factor (GEF) 6 (ARHGEF6))

Alternative Name: ARHGEF6 (ARHGEF6 Products)

Synonyms: COOL2 antibody, Cool-2 antibody, MRX46 antibody, PIXA antibody, alpha-PIX antibody, alphaPIX antibody, 1600028C08Rik antibody, 1700038J06Rik antibody, 4930592P22Rik antibody, Rac/Cdc42 guanine nucleotide exchange factor 6 antibody, Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 antibody, ARHGEF6 antibody, Arhgef6 antibody

Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.Synonyms: Alpha-Pix, COOL-2, COOL2, KIAA0006, PAK-interacting exchange factor alpha, PIXA, Rac/Cdc42 guanine nucleotide exchange factor 6, Rho guanine nucleotide exchange factor 6

Gene ID: 9459

NCBI Accession: NP_004831

Pathways: Neurotrophin Signaling Pathway