CAD antibody (Middle Region)

Catalog No. ABIN950999

Product Details anti-CAD Antibody

Target: CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD))

Binding Specificity: AA 787-816, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CAD.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 787-816 amino acids from the Central region of human CAD

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CAD

Target: CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD))

Alternative Name: CAD Protein (CAD Products)

Synonyms: Cpad antibody, AU018859 antibody, 2410008J01Rik antibody, cb456 antibody, wu:fc30c12 antibody, wu:fc33d01 antibody, wu:fc67g02 antibody, si:dkey-221h15.3 antibody, CAD antibody, xcad antibody, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase antibody, CAD antibody, Cad antibody, cad antibody

Background: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.Synonyms: ACTase, Aspartate carbamoyltransferase, DHOase, Dihydroorotase, GATase, Glutamine-dependent carbamoyl-phosphate synthase

Molecular Weight: 242984 Da

Gene ID: 790

NCBI Accession: NP_004332

Pathways: Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process