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CARD16 antibody (N-Term)

CARD16 Reactivity: Human WB, FACS, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN951040
  • Target See all CARD16 Antibodies
    CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))
    Binding Specificity
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    AA 44-73, N-Term
    Reactivity
    Human
    Host
    • 21
    • 4
    • 1
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CARD16 antibody is un-conjugated
    Application
    • 15
    • 13
    • 8
    • 4
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to COP1.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography on Protein A
    Immunogen
    KLH conjugated synthetic peptide between 44-73 amino acids from the N-terminal region of human COP1
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CARD16 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CARD16 (Caspase Recruitment Domain Family, Member 16 (CARD16))
    Alternative Name
    CARD16 / COP1 (CARD16 Products)
    Synonyms
    COP antibody, COP1 antibody, PSEUDO-ICE antibody, caspase recruitment domain family member 16 antibody, CARD16 antibody
    Background
    Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.Synonyms: CARD only domain-containing protein 1, Caspase recruitment domain-containing protein 16, Caspase-1 inhibitor COP, PSEUDO-ICE, Pseudo interleukin-1 beta converting enzyme
    Molecular Weight
    22625 Da
    Gene ID
    114769
    NCBI Accession
    NP_001017534
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