KCNC3 antibody (Internal Region)

Catalog No. ABIN952996

Product Details anti-KCNC3 Antibody

Target: KCNC3 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3))

Binding Specificity: AA 317-328, Internal Region

Reactivity: Human, Mouse, Rat, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This KCNC3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-HISNKTVTQA SP

Specificity: Recognizes KCNC3 / Kv3.3 (317-328).

Cross-Reactivity (Details): Species reactivity (expected):Human, Pig.
Species reactivity (tested):Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_004968.2. Genename: KCNC3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KCNC3

Target: KCNC3 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3))

Alternative Name: KCNC3 (KCNC3 Products)

Synonyms: kcnc3-A antibody, Kv3.1 antibody, KShIIID antibody, Kcr2-3 antibody, Kv3.3 antibody, KSHIIID antibody, KV3.3 antibody, SCA13 antibody, kcnc1 antibody, kshiiid antibody, kv3.3 antibody, sca13 antibody, potassium voltage-gated channel subfamily C member 3 antibody, potassium channel, voltage gated Shaw related subfamily C, member 1 S homeolog antibody, potassium voltage gated channel, Shaw-related subfamily, member 3 antibody, potassium channel, voltage gated Shaw related subfamily C, member 3 L homeolog antibody, potassium voltage-gated channel, Shaw-related subfamily, member 3 antibody, KCNC3 antibody, kcnc1.S antibody, Kcnc3 antibody, kcnc3.L antibody

Background: KCNC3 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.Synonyms: KSHIIID, Potassium voltage-gated channel subfamily C member 3, Voltage-gated potassium channel subunit Kv3.3

Gene ID: 3748

NCBI Accession: NP_004968