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MLH1 antibody (Middle Region)
MLH1
Reactivity: Human
WB, FACS, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MLH1 Antibody
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Target
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MLH1
(MutL Homolog 1 (MLH1))
Binding Specificity
All epitopes for MLH1 antibodies
AA 459-488, Middle Region
Reactivity
All reactivities for MLH1 antibodies
Human
Host
All hosts for MLH1 antibodies
Rabbit
Clonality
All clonalities for MLH1 antibodies
Polyclonal
Conjugate
All conjugates for MLH1 antibodies
This MLH1 antibody is un-conjugated
Application
All applications for MLH1 antibodies
Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
Specificity
This antibody recognizes MLH1.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Purification
Purified through a Protein A column followed by peptide affinity purification
Immunogen
Synthetic peptide - KLH conjugated - corresponding to the central region (between 459-488aa) of human MLH1.
Isotype
Ig Fraction
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Discover our top product MLH1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) Sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for MLH1
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Target
MLH1
(MutL Homolog 1 (MLH1))
Alternative Name
MLH1 (MLH1 Products )
Synonyms
CG11482 antibody, Dmel\\CG11482 antibody, dmlh-1 antibody, dmlh1 antibody, zgc:66301 antibody, MLH1 antibody, LOC100232198 antibody, 1110035C23Rik antibody, AI317206 antibody, AI325952 antibody, AI561766 antibody, COCA2 antibody, FCC2 antibody, HNPCC antibody, HNPCC2 antibody, hMLH1 antibody, mutL homolog 1 antibody, CG11482 gene product from transcript CG11482-RB antibody, mutL homolog 1 S homeolog antibody, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) antibody, DNA mismatch repair protein Mlh1 antibody, MLH1 antibody, Mlh1 antibody, mlh1.S antibody, mlh1 antibody, LOC588545 antibody
Background
The MLH1 gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.Synonyms: COCA2, DNA mismatch repair protein Mlh1
Gene ID
4292
NCBI Accession
NP_000240
Pathways
DNA Damage Repair , Production of Molecular Mediator of Immune Response
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