zgc:63897 antibody, PLEKHF1 antibody, APPD antibody, LAPF antibody, PHAFIN1 antibody, ZFYVE15 antibody, 1810013P09Rik antibody, pleckstrin homology domain containing, family F (with FYVE domain) member 1 antibody, pleckstrin homology and FYVE domain containing 1 antibody, plekhf1 antibody, PLEKHF1 antibody, Plekhf1 antibody
Background
PLEKHF1 may induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.Synonyms: APPD, Apoptosis-inducing protein, LAPF, Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains, PH domain-containing family F member 1, Phafin 1, Phafin-1, Pleckstrin homology domain-containing family F member 1, ZFYVE15, Zinc finger FYVE domain-containing protein 15