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SAR1B antibody (Middle Region)

SAR1B Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN954670
  • Target See all SAR1B Antibodies
    SAR1B (SAR1 Homolog B (SAR1B))
    Binding Specificity
    • 9
    • 7
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 96-124, Middle Region
    Reactivity
    • 32
    • 15
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 30
    • 2
    • 1
    Rabbit
    Clonality
    • 31
    • 2
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SAR1B antibody is un-conjugated
    Application
    • 25
    • 19
    • 16
    • 13
    • 4
    • 3
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    Recognizes SAR1B (Center).
    Purification
    Protein A column followed by peptide Affinity purification
    Immunogen
    KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of Human SAR1B Genename: SAR1B
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SAR1B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    SAR1B (SAR1 Homolog B (SAR1B))
    Alternative Name
    SAR1B (SAR1B Products)
    Synonyms
    SAR1 antibody, SAR1B antibody, SARA2 antibody, 2310075M17Rik antibody, 2900019I22Rik antibody, CMRD antibody, Sara1b antibody, Sara2 antibody, Sarb antibody, cmrd antibody, gtbpb antibody, sar1a antibody, sara2 antibody, SARA1B antibody, ANDD antibody, GTBPB antibody, zgc:73204 antibody, secretion associated Ras related GTPase 1B antibody, hypothetical protein antibody, SAR1 homolog B (S. cerevisiae) antibody, secretion associated, Ras related GTPase 1B L homeolog antibody, secretion associated, Ras related GTPase 1B antibody, SAR1B antibody, Sar1B antibody, sar1b antibody, Sar1b antibody, sar1b.L antibody
    Background
    SAR1B belongs to the small GTPase superfamily, SAR1 family. It is involved in transport from the endoplasmic reticulum to the Golgi apparatus and is activated by the guanine nucleotide exchange factor PREB. SAR1B is involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The conditions are characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Cellular localization: Endoplasmic reticulum membrane, Peripheral membrane protein. Golgi apparatus, Golgi stack membrane, Peripheral membrane protein. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.Synonyms: GTBPB, GTP-binding protein SAR1b, SAR1B, SARA2, SARB
    Gene ID
    51128
    NCBI Accession
    NP_001028675
    Pathways
    Lipid Metabolism
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