Endoplasmic Reticulum Protein 44 (ERP44) antibody

Details for Product No. ABIN955403
Target
Reactivity
Human
38
7
6
3
3
3
3
3
3
3
2
2
2
2
1
1
1
Host
Mouse
25
7
7
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
26
18
10
10
7
3
1
1
Options
Immunogen ERP44 antibody was raised against TXNDC4 (AAH05374, 30 a.a. ~ 407 a.a) full length recombinant protein with GST tag.
Clone 3C7
Isotype IgG2b
Specificity This antibody recognizes ERP44 / TXNDC4.
Purification Protein A Chromatography
Target
Alternative Name TXNDC4 / ERP44 (ERP44 Antibody Abstract)
Background TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.Synonyms: Endoplasmic reticulum resident protein ERp44, KIAA0573, Thioredoxin domain-containing protein 4
Gene ID 23071
NCBI Accession NP_055866
UniProt Q9BS26
Pathways Cell RedoxHomeostasis, SARS-CoV-2 Protein Interactome
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.35 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C or lower.
Images
Image no. 1 for anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (ABIN955403) anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (Image 1)
Image no. 2 for anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (ABIN955403) anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (Image 2)
Image no. 3 for anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (ABIN955403) anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (Image 3)
Image no. 4 for anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (ABIN955403) anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (Image 4)
Image no. 5 for anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (ABIN955403) anti-Endoplasmic Reticulum Protein 44 (ERP44) antibody (Image 5)