RENT2/UPF2 antibody (Middle Region)

Catalog No. ABIN955462

Product Details anti-RENT2/UPF2 Antibody

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Binding Specificity: AA 633-660, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RENT2/UPF2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody detects UPF2 / RENT2 (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 633-660 amino acids from the Central region of human UPF2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for RENT2/UPF2

Target: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Alternative Name: UPF2 / RENT2 (UPF2 Products)

Synonyms: HUPF2 antibody, RENT2 antibody, smg-3 antibody, UPF2, regulator of nonsense mediated mRNA decay antibody, UPF2 regulator of nonsense transcripts homolog (yeast) antibody, UPF2 antibody, Upf2 antibody, upf2 antibody

Background: UPF2 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p.Synonyms: KIAA1408, Regulator of nonsense transcripts 2, Up-frameshift suppressor 2 homolog

Gene ID: 26019

NCBI Accession: NP_056357