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RECQL2 antibody (Middle Region, Thr802)

WRN Reactivity: Human WB, FACS, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN955584
  • Target See all RECQL2 (WRN) Antibodies
    RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))
    Binding Specificity
    • 7
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 794-825, Middle Region, Thr802
    Reactivity
    • 41
    • 2
    • 1
    Human
    Host
    • 34
    • 7
    Rabbit
    Clonality
    • 34
    • 7
    Polyclonal
    Conjugate
    • 24
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RECQL2 antibody is un-conjugated
    Application
    • 31
    • 21
    • 12
    • 7
    • 6
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects WRN (Center).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Protein A column; followed by peptide affinity purification
    Immunogen
    KLH conjugated synthetic peptide between 794-825 (T802 amino acids from the Central region of human WRN
    Isotype
    Ig Fraction
    Top Product
    Discover our top product WRN Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
  • Target
    RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))
    Alternative Name
    WRN (WRN Products)
    Synonyms
    RECQ3 antibody, RECQL2 antibody, RECQL3 antibody, xBLM antibody, recq2 antibody, recql2 antibody, recql3 antibody, AI846146 antibody, ffa-1 antibody, xwrn antibody, RGD1564788 antibody, Werner syndrome RecQ like helicase antibody, mediator of RNA polymerase II transcription subunit 34 antibody, Bloom syndrome RecQ like helicase antibody, Werner syndrome, RecQ helicase-like L homeolog antibody, WRN antibody, LOC9327212 antibody, blm antibody, Wrn antibody, wrn.L antibody
    Background
    This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.Synonyms: DNA helicase, Exonuclease WRN, RECQ3, RECQL2, RecQ protein-like 2, RecQ-like type 3, RecQ3, Werner syndrome ATP-dependent helicase
    Gene ID
    7486
    NCBI Accession
    NP_000544
    Pathways
    DNA Damage Repair
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