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ATP2C1 antibody

ATP2C1 Reactivity: Human, Monkey ELISA, WB, IHC Host: Mouse Monoclonal 4G12 unconjugated
Catalog No. ABIN965621
  • Target See all ATP2C1 Antibodies
    ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))
    Reactivity
    • 41
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Monkey
    Host
    • 36
    • 5
    Mouse
    Clonality
    • 38
    • 3
    Monoclonal
    Conjugate
    • 21
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATP2C1 antibody is un-conjugated
    Application
    • 28
    • 21
    • 7
    • 7
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Purification
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of ATP2C1 expressed in E. Coli.
    Clone
    4G12
    Isotype
    IgG1
    Top Product
    Discover our top product ATP2C1 Primary Antibody
  • Application Notes
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Yokota, Sawamura: "Hailey-Hailey disease with affective disorder: report of a case with novel ATP2C1 gene mutation." in: Journal of dermatological science, Vol. 43, Issue 2, pp. 150-1, (2006) (PubMed).

    Majore, Biolcati, Barboni, Cannistraci, Binni, Crisi, Picardo, Grammatico: "ATP2C1 gene mutation analysis in Italian patients with Hailey-Hailey disease." in: The Journal of investigative dermatology, Vol. 125, Issue 5, pp. 933-5, (2005) (PubMed).

  • Target
    ATP2C1 (ATPase, Ca++ Transporting, Type 2C, Member 1 (ATP2C1))
    Alternative Name
    ATP2C1 (ATP2C1 Products)
    Synonyms
    ATP2C1 antibody, ATP2C1A antibody, BCPM antibody, HHD antibody, PMR1 antibody, SPCA1 antibody, hSPCA1 antibody, Spca1 antibody, si:dkey-11p23.6 antibody, SPCA antibody, 1700121J11Rik antibody, AW061228 antibody, D930003G21Rik antibody, pmr1 antibody, ATPase secretory pathway Ca2+ transporting 1 antibody, ATPase, Ca++ transporting, type 2C, member 1 antibody, ATPase, Ca++-sequestering antibody, ATP2C1 antibody, atp2c1 antibody, Atp2c1 antibody
    Background
    ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
    Synonyms: HHD, BCPM, PMR1, SPCA1
    Molecular Weight
    100kDa
    Gene ID
    27032
    Pathways
    Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process
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