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BMPR2 antibody

BMPR2 Reactivity: Human, Mouse, Rat, Monkey WB, ELISA, IHC, IF Host: Mouse Monoclonal 3F6 unconjugated
Catalog No. ABIN965687
  • Target See all BMPR2 Antibodies
    BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))
    Reactivity
    • 70
    • 43
    • 16
    • 3
    • 1
    Human, Mouse, Rat, Monkey
    Host
    • 64
    • 6
    • 1
    Mouse
    Clonality
    • 65
    • 6
    Monoclonal
    Conjugate
    • 34
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This BMPR2 antibody is un-conjugated
    Application
    • 54
    • 35
    • 28
    • 22
    • 13
    • 13
    • 13
    • 10
    • 8
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purification
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human BMPR2 expressed in E. Coli.
    Clone
    3F6
    Isotype
    IgG1
    Top Product
    Discover our top product BMPR2 Primary Antibody
  • Application Notes
    Western Bloting: 1/500 - 1/2000.
    Immunohistochemistry: 1/200 - 1/1000.
    Immunofluorescence: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
  • Phillips, Poling, Phillips, Stanton, Austin, Cogan, Wheeler, Yu, Newman, Dietz, Loyd: "Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 5, pp. 359-65, (2008) (PubMed).

  • Target
    BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))
    Alternative Name
    BMPR2 (BMPR2 Products)
    Synonyms
    BMPR-II antibody, BMPR3 antibody, BMR2 antibody, BRK-3 antibody, PPH1 antibody, T-ALK antibody, 2610024H22Rik antibody, AL117858 antibody, AW546137 antibody, BB189135 antibody, BMP-2 antibody, BMPR-2 antibody, BMPRII antibody, Gm20272 antibody, Bmpr-II antibody, bmprii antibody, bone morphogenetic protein receptor type 2 antibody, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antibody, bone morphogenetic protein receptor, type II (serine/threonine kinase) antibody, BMPR2 antibody, bmpr2b antibody, Bmpr2 antibody
    Background
    This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
    Synonyms: BMR2, PPH1, BMPR3, BRK-3, TALK, BMPR-II, FLJ41585, FLJ76945, BMPR2
    Molecular Weight
    115kDa
    Gene ID
    659
    Pathways
    Growth Factor Binding
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