Integrin beta 3 antibody

Catalog No. ABIN965812

Product Details anti-Integrin beta 3 Antibody

Target: Integrin beta 3 (ITGB3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 3 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Concentrated.

Immunogen: Phytohemagglutinin-stimulated Human Mononuclear Cells

Clone: Y2-51

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry: (Paraffin/Frozen (acetone fixed)) 1:50-1:100, FLOW.
Staining Procedure: Prolonged fixation in buffered formalin can destroy the epitope. The antibody may be used at a dilution of 1:50 -1:100 in IHC. When using paraffin-embedded and formalin-fixed tissues, enzymatic predigestion is required. The optimal conditions should be determined by the individual laboratory.

Comment:

Cellular Localization: Cell Membrane.
Recommended Positive Control: Lymphoid Tissues

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/ml.

Buffer: 20 mM Tris-Borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing Fetal Bovine Serum, BMC-6 Carrier Polysaccharides, Carrier Protein, pH 7.5

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-Integrin beta 3 antibody (ABIN965812)

Ford-Hutchinson: "Regulation of leukotriene biosynthesis." in: Cancer metastasis reviews, Vol. 13, Issue 3-4, pp. 257-67, (1995) (PubMed).

Target Details for Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Alternative Name: CD61, Platelet Glycoprotein IIIa (ITGB3 Products)

Synonyms: BDPLT16 antibody, BDPLT2 antibody, CD61 antibody, GP3A antibody, GPIIIa antibody, GT antibody, INGRB3 antibody, integrin antibody, INTB3 antibody, GPIIIA antibody, cd61 antibody, gp3a antibody, itgb3 antibody, itgb3.2 antibody, itgb3.1 antibody, integrin subunit beta 3 antibody, integrin beta 3 antibody, integrin subunit beta 3 L homeolog antibody, integrin beta 3a antibody, integrin beta 3b antibody, ITGB3 antibody, Itgb3 antibody, itgb3.L antibody, itgb3a antibody, itgb3b antibody

Background: This antibody reacts with platelet glycoprotein IIIa, a 110 kD glycoprotein present on human platelets and megakaryocytic progenitors. This antibody reacts with platelets, megakaryocytes, megakaryoblasts, endothelium, and osteoclasts.

Gene ID: 3690

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex