Connexin 43/GJA1 antibody

Catalog No. ABIN965918

Product Details anti-Connexin 43/GJA1 Antibody

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Connexin 43/GJA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: Connexin43 (Ab-367) antibody detects endogenous levels of total Connexin43 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Connexin43 around the phosphorylation site of serine 367 (R-A-SP-S-R).

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Connexin 43/GJA1 antibody (ABIN965918)

Matsushita, Kurihara, Watanabe, Okada, Sakai, Amano: "Alterations of phosphorylation state of connexin 43 during hypoxia and reoxygenation are associated with cardiac function." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 54, Issue 3, pp. 343-53, (2006) (PubMed).

Bao, Altenberg, Reuss: "Mechanism of regulation of the gap junction protein connexin 43 by protein kinase C-mediated phosphorylation." in: American journal of physiology. Cell physiology, Vol. 286, Issue 3, pp. C647-54, (2004) (PubMed).

Solan, Fry, TenBroek, Lampe: "Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation." in: Journal of cell science, Vol. 116, Issue Pt 11, pp. 2203-11, (2003) (PubMed).

Li, Waldo, Linask, Chen, Wessels, Parmacek, Kirby, Lo: "An essential role for connexin43 gap junctions in mouse coronary artery development." in: Development (Cambridge, England), Vol. 129, Issue 8, pp. 2031-42, (2002) (PubMed).

Target Details for Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Alternative Name: Connexin 43 (GJA1 Products)

Synonyms: AVSD3 antibody, CX43 antibody, DFNB38 antibody, GJAL antibody, HLHS1 antibody, HSS antibody, ODDD antibody, Cx43 antibody, AU042049 antibody, AW546267 antibody, Cnx43 antibody, Cx43alpha1 antibody, Gja-1 antibody, Npm1 antibody, connexin43 antibody, cx43a1 antibody, gja1 antibody, zfCx43.3 antibody, connexin 43 antibody, gja1-A antibody, cx43 antibody, gjal antibody, oddd antibody, dfnb38 antibody, gap junction protein alpha 1 antibody, gap junction protein, alpha 1 antibody, connexin 43 antibody, gap junction protein alpha 1 L homeolog antibody, CONNEXIN 43 protein antibody, GJA1 antibody, Gja1 antibody, cx43 antibody, gja1.L antibody, gja1 antibody, CONNEXIN 43 antibody

Pathways: MAPK Signaling, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization