M-CSF/CSF1 antibody

Catalog No. ABIN965939

Product Details anti-M-CSF/CSF1 Antibody

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This M-CSF/CSF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CSF1 expressed in E. Coli.

Clone: 2D10

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-M-CSF/CSF1 antibody (ABIN965939)

Price, Choi, Rosenberg, Stanley: "The predominant form of secreted colony stimulating factor-1 is a proteoglycan." in: The Journal of biological chemistry, Vol. 267, Issue 4, pp. 2190-9, (1992) (PubMed).

Sakai, Umeda, Suzuki, Ishimatsu, Shikita: "Macrophage colony-stimulating factor purified from normal human urine. Amino-terminal sequence and amino acid composition." in: FEBS letters, Vol. 222, Issue 2, pp. 341-4, (1987) (PubMed).

Target Details for M-CSF/CSF1

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Alternative Name: CSF1 (CSF1 Products)

Synonyms: CSF-1 antibody, MCSF antibody, C87615 antibody, Csfm antibody, op antibody, csf1-1 antibody, zgc:172186 antibody, CSF1 antibody, csf1-2 antibody, zgc:158436 antibody, colony stimulating factor 1 antibody, colony stimulating factor 1 (macrophage) antibody, colony stimulating factor 1a (macrophage) antibody, macrophage colony-stimulating factor 1 antibody, macrophage colony stimulating factor antibody, colony stimulating factor 1b (macrophage) antibody, CSF1 antibody, Csf1 antibody, csf1a antibody, LOC396599 antibody, LOC100860895 antibody, csf1b antibody

Background: CSF1, also known as MCSF, is a four-alpha-helical bundle cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. This protein may be involved in development of the placenta.
Synonyms: MCSF

Molecular Weight: 60kDa

Gene ID: 1435

Pathways: RTK Signaling