EGFR antibody (Epidermal Growth Factor Receptor) (pTyr869)

Details for Product anti-EGFR Antibody No. ABIN966039
Target
Binding Specificity
pTyr869
48
45
39
36
33
32
31
28
26
26
26
25
24
24
23
22
21
20
17
17
17
16
15
15
15
15
15
14
14
13
13
9
9
9
8
6
6
6
6
6
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse, Rat
1164
497
465
21
21
13
12
11
11
7
7
4
4
3
2
2
2
2
2
1
1
1
1
1
Host
Rabbit
818
303
18
13
13
5
2
1
1
1
Conjugate
This EGFR antibody is un-conjugated
86
44
41
39
28
28
28
28
28
26
21
17
16
16
16
16
16
5
5
5
5
5
5
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (IHC)
687
346
272
216
210
168
154
152
50
47
41
34
26
22
17
17
12
8
6
5
4
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Options
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human EGFR around the phosphorylation site of tyrosine 869 (K-E-YP-H-A).
Specificity EGFR (phospho-Tyr869) antibody detects endogenous levels of EGFR only when phosphorylated at tyrosine 869.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using nonphosphopeptide corresponding to the phosphorylation site.
Target
Alternative Name EGFR (EGFR Antibody Abstract)
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
Application Notes WB: 1:500~1:1000.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Yamamasu, Sato, Ogita, Inoue: "Role of glutathione metabolism and apoptosis in the regression of liver hemopoiesis." in: Free radical biology & medicine, Vol. 23, Issue 1, pp. 100-9, 1997 (PubMed).

ORourke, Qian, Zhang, Davis, Nute, Meinkoth, Greene: "Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 7, pp. 3250-5, 1997 (PubMed).

Goldstein, Li, Wang, Heidaran, Aaronson, Shinn, Schlegel, Pierce et al.: "The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine ..." in: Journal of virology, Vol. 68, Issue 7, pp. 4432-41, 1994 (PubMed).

Kanner, Reynolds, Parsons: "Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells." in: Molecular and cellular biology, Vol. 11, Issue 2, pp. 713-20, 1991 (PubMed).